Reserve concomitant prescribing of such medicines in individuals for whom other cure solutions are insufficient. Limit dosages and durations to the minimal expected. Monitor carefully for signs of respiratory depression and sedation.
fluvoxamine will boost the degree or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Prescribers need to recommend caregivers they count on to generally be knowledgeable straight away if a individual develops any new results which aren't typical in the individual’s attribute seizure episode
griseofulvin will reduce the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Suicidal Conduct and Ideation: Antiepileptic medications (AEDs), like APTIOM, increase the risk of suicidal thoughts or behavior. Everyone taking into consideration prescribing APTIOM or almost every other AED ought to equilibrium this threat with the risk of untreated health issues. Epilepsy and many other illnesses for which AEDs are prescribed are on their own associated with morbidity and mortality and an elevated possibility of suicidal thoughts and habits.
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B: Can be acceptable. Possibly animal scientific tests present no possibility but human reports not available or animal research showed insignificant hazards and human scientific studies performed and showed no danger.
withdrawal reactions, which includes seizures, which may be life-threatening; use gradual taper when discontinuing therapy to lower withdrawal reactions chance
fosphenytoin will reduce the level or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
sage decreases consequences of diazepam by pharmacodynamic antagonism. Slight/Significance Not known. Theoretical interaction; some species of sage may result in convulsions.
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anastrozole will increase the amount or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.
Comment: Teduglutide may possibly maximize absorption of get more info concomitant PO medications; caution with with medicine requiring titration or those using a slim therapeutic index; dose adjustment may be necessary.
diazepam and daridorexant both of those enhance sedation. Modify Therapy/Observe Intently. Coadministration increases possibility of CNS despair, which can lead to additive impairment of psychomotor functionality and result in daytime impairment.